It never ceases to amaze me how much we don^t know page 1
Adenosine
11th January 2012, 09:12 AM
Every question that gets answered throws up two more.
Take cell biology for example. There are thousands of proteins involved in cellular processes but for many of them all we have is a name. We don't know what they interact with, we don't know what they do exactly. Case in point.
Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane receptor found in epithelial tissue. In endometrial tissue, when stimulated by ligand it signals through two different paths and induces mitosis, or cell division. Once stimulated though, the receptor needs to be taken out of circulation, literally. Depending on the ligand it either gets endocytosed and degraded by lysosomes or gets endocytosed and then recycled back to the cell membrane. This has been known for a while and has pretty much entered into dogma.
However, the receptor has been seen in the nucleus, specifically in or on nucleoli. The nucleolus is the site of ribosomal assembly, where RNA and proteins combine to make the structures that turn messenger RNA into protein. It is also a store of proteins used in signalling in the cell cycle.
So what is FGFR2 doing there? We don't know, but we will find out.
What other big, or little, questions need to be answered?
Take cell biology for example. There are thousands of proteins involved in cellular processes but for many of them all we have is a name. We don't know what they interact with, we don't know what they do exactly. Case in point.
Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane receptor found in epithelial tissue. In endometrial tissue, when stimulated by ligand it signals through two different paths and induces mitosis, or cell division. Once stimulated though, the receptor needs to be taken out of circulation, literally. Depending on the ligand it either gets endocytosed and degraded by lysosomes or gets endocytosed and then recycled back to the cell membrane. This has been known for a while and has pretty much entered into dogma.
However, the receptor has been seen in the nucleus, specifically in or on nucleoli. The nucleolus is the site of ribosomal assembly, where RNA and proteins combine to make the structures that turn messenger RNA into protein. It is also a store of proteins used in signalling in the cell cycle.
So what is FGFR2 doing there? We don't know, but we will find out.
What other big, or little, questions need to be answered?
nostrum
12th January 2012, 03:30 AM
We need to understand how the chemistry of the brain works.
OmicronPersei8
21st April 2015, 09:14 PM
Did they find it out yet?
nostrum
21st April 2015, 09:17 PM
Ketamine has inched us closer.
ETA is thread resurrection like pyromania: unfathomable?
ETA is thread resurrection like pyromania: unfathomable?
OmicronPersei8
21st April 2015, 09:19 PM
wut?
gib
21st April 2015, 10:44 PM
yet again, Deadlokd still not found the cure for cancer
borealis
21st April 2015, 10:58 PM
yet again, Deadlokd still not found the cure for cancer
He's come so close!
Maybe he needs more grant money.
He's come so close!
Maybe he needs more grant money.
MSG
21st April 2015, 11:00 PM
He'd just use it to get on TV
nostrum
21st April 2015, 11:03 PM
We all would
MSG
21st April 2015, 11:06 PM
I wouldn't; I'd add it to my bank of tax-free retirement savings because :fuckyou:
Timewave
21st April 2015, 11:33 PM
Chemicals in the brain?
gib
21st April 2015, 11:59 PM
yes please
Timewave
22nd April 2015, 12:04 AM
I think I have been mixing my uppers and downers wrong for years.
:ausfag:
:ausfag:
Timewave
22nd April 2015, 12:07 AM
wrong kinda fluid retention too. :nod:
some kinda pill fixed it, :nod:
got rid of the water and kept the piss.
Great pills. :christyes:
You could be dehydrated, drunk and hungover all at the same time.
some kinda pill fixed it, :nod:
got rid of the water and kept the piss.
Great pills. :christyes:
You could be dehydrated, drunk and hungover all at the same time.
MSG
22nd April 2015, 12:09 AM
Diuretics ftw
Timewave
22nd April 2015, 12:14 AM
ftw?
fuck the world?
fuck the world?
MSG
22nd April 2015, 12:15 AM
_or _he _in
nostrum
22nd April 2015, 12:30 AM
We don't know
Timewave
22nd April 2015, 12:31 AM
Ketamine has inched us closer.
ETA is thread resurrection like pyromania: unfathomable?
maybe more like gods who get themselves killed so they can impress everybody by making themselves alive again.
where do the gods go when they die?
They don't go to heaven where the angels fly.
they go to a lake of fire and fry.
don't see them again till the 4th of july.
ETA is thread resurrection like pyromania: unfathomable?
maybe more like gods who get themselves killed so they can impress everybody by making themselves alive again.
where do the gods go when they die?
They don't go to heaven where the angels fly.
they go to a lake of fire and fry.
don't see them again till the 4th of july.
Zeluvia
22nd April 2015, 01:35 AM
ftw?
fuck the world?
yes they took Fuck the World, which us incorrigible reprobates know all about and changed it to For The Win, which I found confusing a few years ago too....
fuck the world?
yes they took Fuck the World, which us incorrigible reprobates know all about and changed it to For The Win, which I found confusing a few years ago too....
Timewave
22nd April 2015, 02:48 AM
ftw?
fuck the world?
yes they took Fuck the World, which us incorrigible reprobates know all about and changed it to For The Win, which I found confusing a few years ago too....
You and me buddy, :angel:
We'll keep it as fuck the world. :cheer:
fuck the world?
yes they took Fuck the World, which us incorrigible reprobates know all about and changed it to For The Win, which I found confusing a few years ago too....
You and me buddy, :angel:
We'll keep it as fuck the world. :cheer:
Requiem
22nd April 2015, 09:58 AM
It was always for the win. RnR, the authority on these things at the time, confirms.
(heh I typed "it was always ftw" at first while thinking "for the win")
(heh I typed "it was always ftw" at first while thinking "for the win")
Adenosine
22nd April 2015, 10:22 AM
yet again, Deadlokd still not found the cure for cancer
He's come so close!
Maybe he needs more grant money.
Yes please.
He'd just use it to get on TV
I'm already on TV. I'd use it to move to the Caribbean. That's important for the research.
He's come so close!
Maybe he needs more grant money.
Yes please.
He'd just use it to get on TV
I'm already on TV. I'd use it to move to the Caribbean. That's important for the research.
Majiffy
23rd April 2015, 05:16 AM
Ketamine has inched us closer.
Consider me a willing participant for this study.
Consider me a willing participant for this study.
Zeluvia
30th April 2015, 02:32 PM
It was always for the win. RnR, the authority on these things at the time, confirms.
(heh I typed "it was always ftw" at first while thinking "for the win")
Who is RnR? When it was tatoo'd on one of my early boyfriends fathers knuckles in prison, it was Fuck the World.
(heh I typed "it was always ftw" at first while thinking "for the win")
Who is RnR? When it was tatoo'd on one of my early boyfriends fathers knuckles in prison, it was Fuck the World.
Zeluvia
30th April 2015, 02:35 PM
And now for something completely different... PFM (pure fucking magic)
The EM drive has been tested in hard vacuum. It works. US, UK and China are all testing this thing, and still no one knows WHY the hell it works.
After consistent reports of thrust measurements from EM Drive experiments in the US, UK, and China – at thrust levels several thousand times in excess of a photon rocket, and now under hard vacuum conditions – the question of where the thrust is coming from deserves serious inquiry.
A note of caution is that Dr. White’s simulations do not assume that the Quantum Vacuum is indestructible and immutable. The mainstream physics community assumes the Quantum Vacuum is indestructible and immutable because of the experimental observation that a fundamental particle like an electron (or a positron) has the same properties (e.g. mass, charge or spin), regardless of when or where the particle was created, whether now or in the early universe, through astrophysical processes or in a laboratory.
Another reason is that the Quantum Vacuum is assumed to be the lowest possible (time-averaged) energy that a quantum physical system may have, and therefore it should not be possible to extract momentum or energy from the Quantum Vacuum.http://www.nasaspaceflight.com/2015/04/evaluating-nasas-futuristic-em-drive/
Yes, Carlsson, this is a question about thrust.
The EM drive has been tested in hard vacuum. It works. US, UK and China are all testing this thing, and still no one knows WHY the hell it works.
After consistent reports of thrust measurements from EM Drive experiments in the US, UK, and China – at thrust levels several thousand times in excess of a photon rocket, and now under hard vacuum conditions – the question of where the thrust is coming from deserves serious inquiry.
A note of caution is that Dr. White’s simulations do not assume that the Quantum Vacuum is indestructible and immutable. The mainstream physics community assumes the Quantum Vacuum is indestructible and immutable because of the experimental observation that a fundamental particle like an electron (or a positron) has the same properties (e.g. mass, charge or spin), regardless of when or where the particle was created, whether now or in the early universe, through astrophysical processes or in a laboratory.
Another reason is that the Quantum Vacuum is assumed to be the lowest possible (time-averaged) energy that a quantum physical system may have, and therefore it should not be possible to extract momentum or energy from the Quantum Vacuum.http://www.nasaspaceflight.com/2015/04/evaluating-nasas-futuristic-em-drive/
Yes, Carlsson, this is a question about thrust.
MondoVman
30th April 2015, 08:27 PM
"the EM Drive results have yet to be falsified." - neat results, but bullshit wording!
Fixed wording: "the EM Drive results (of NASASpaceflight.com group) have yet to be verified/repeated by others."
- Science 101
Fixed wording: "the EM Drive results (of NASASpaceflight.com group) have yet to be verified/repeated by others."
- Science 101
MSG
30th April 2015, 11:05 PM
It was always for the win. RnR, the authority on these things at the time, confirms.
(heh I typed "it was always ftw" at first while thinking "for the win")
Who is RnR? When it was tatoo'd on one of my early boyfriends fathers knuckles in prison, it was Fuck the World. RnR was the Web forum Rants 'n' Raves, a precursor to TalkRational, now gone to the Great Forum Cemetery in the Clouds
(heh I typed "it was always ftw" at first while thinking "for the win")
Who is RnR? When it was tatoo'd on one of my early boyfriends fathers knuckles in prison, it was Fuck the World. RnR was the Web forum Rants 'n' Raves, a precursor to TalkRational, now gone to the Great Forum Cemetery in the Clouds
gib
30th April 2015, 11:09 PM
Adenosine thread
nostrum
30th April 2015, 11:59 PM
finally an explanation
Zeluvia
1st May 2015, 03:05 AM
It was always for the win. RnR, the authority on these things at the time, confirms.
(heh I typed "it was always ftw" at first while thinking "for the win")
Who is RnR? When it was tatoo'd on one of my early boyfriends fathers knuckles in prison, it was Fuck the World.
RnR was the Web forum Rants 'n' Raves, a precursor to TalkRational, now gone to the Great Forum Cemetery in the Clouds
Ah, I visited there a bit, from what I read I think it probably went to the 5th level of Forum Hell.
Fuck the World as a prison tatoo predates the internet.
(heh I typed "it was always ftw" at first while thinking "for the win")
Who is RnR? When it was tatoo'd on one of my early boyfriends fathers knuckles in prison, it was Fuck the World.
RnR was the Web forum Rants 'n' Raves, a precursor to TalkRational, now gone to the Great Forum Cemetery in the Clouds
Ah, I visited there a bit, from what I read I think it probably went to the 5th level of Forum Hell.
Fuck the World as a prison tatoo predates the internet.
Zeluvia
1st May 2015, 03:11 AM
"the EM Drive results have yet to be falsified." - neat results, but bullshit wording!
Fixed wording: "the EM Drive results (of NASASpaceflight.com group) have yet to be verified/repeated by others."
- Science 101
Yes, the hard vacuum tests have not been repeated yet. I am sure China will be all over that shit soon enough.
The scientific community met these NASA tests with skepticism and a number of physicists proposed that the measured thrust force in the US, UK, and China tests was more likely due to (external to the EM Drive cavity) natural thermal convection currents arising from microwave heating (internal to the EM Drive cavity).
Fixed wording: "the EM Drive results (of NASASpaceflight.com group) have yet to be verified/repeated by others."
- Science 101
Yes, the hard vacuum tests have not been repeated yet. I am sure China will be all over that shit soon enough.
The scientific community met these NASA tests with skepticism and a number of physicists proposed that the measured thrust force in the US, UK, and China tests was more likely due to (external to the EM Drive cavity) natural thermal convection currents arising from microwave heating (internal to the EM Drive cavity).
Majiffy
1st May 2015, 11:23 PM
After consistent reports of thrust measurements from EM Drive experiments in the US, UK, and China – at thrust levels several thousand times in excess of a photon rocket, and now under hard vacuum conditions – the question of where the thrust is coming from deserves serious inquiry.
I don't remember an international science team investigating my motion of the ocean...
I don't remember an international science team investigating my motion of the ocean...
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